The Impossible Simulation Here's an idea almost everyone has had, usually late at night: if life began as an unplanned chemical accident, and that accident obeyed nothing but ordinary physics, then a powerful enough computer should be able to rerun it. Load in the early ocean, the lightning, the raw molecules — run the clock forward faster than nature ever could — and somewhere in the search, life should switch on. It's a great idea. It's also impossible, for reasons far stranger than "we don't have a big enough computer." This book proves — with real numbers, not hand-waving — that no simulation, however powerful, could ever brute-force its way to abiogenesis. The configuration space is too large. The chemistry is too expensive to compute accurately. And a discovery from 1961 physics, confirmed in the lab decades later, puts a hard thermodynamic floor under computation itself — one no future engineering can ever cross. But if brute force was never an option, how did physics pull it off? That question turns out to be more interesting than the one we started with — and answering it means touring hydrothermal vents, self-assembling protocells, catalytic RNA, and the strange mathematics of "funnels" that let protein folding, AlphaFold, and possibly the very origin of life all solve searches that should be impossible. Written in the tradition of Nick Lane's biochemistry books — rigorous, narrative-driven, unafraid of real numbers — The Impossible Simulation is for anyone who has ever wondered why some questions can't be computed, only lived through.
Why We Can't Compute Our Way to the Origin of Life — and What That Failure Teaches Us
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